The enzyme reaction rate activity allows students to simulate the effects of variables such as temperature and pH on the reaction rate of the enzyme catalase. This computer simulation is best used after the students have done a wet lab experiment. The value of the simulation is that it requires the students to interpret and analyze the graphical representation of data and it enables the running of mutiple experiments in a short amount of time.

TEACHER RESOURCES Teacher Materials Student Activity Student    Assessment Learning    Goals/Standards COMPUTER MODELS Based on a model from Rick Heupel, Tucson, AZ STELLA Versions isee Player software Right-click to download the models PC Format Mac Format Vensim Version Vensim PLE Software Right-click to download the model Enzyme Reaction Rate Model Web-based Simulation

THE MODEL DIAGRAM THE EQUATIONS Hydrogen_Peroxide(t) = Hydrogen_Peroxide(t - dt) + (-H2O2_Catalysis_Rate) * dt INIT Hydrogen_Peroxide = 1*10^(Hydrogen_Peroxide_Exponent) H2O2_Catalysis_Rate(o) = min(Enzyme_Rate*Available_Enzyme,Hydrogen_Peroxide) Oxygen(t) = Oxygen(t - dt) + (H2O2_Catalysis_Rate) * dt INIT Oxygen = 0 H2O2_Catalysis_Rate(i) = H2O2_Catalysis_Rate(o) * CONVERSION MULTIPLIER CONVERSION MULTIPLIER = 0.5 Water(t) = Water(t - dt) + (H2O2_to_Water_Rate) * dt INIT Water = 0 H2O2_to_Water_Rate = H2O2_Catalysis_Rate Available_Enzyme = 5 Enzyme_Rate = 6e6 * pH_Effect*Temperature_Effect Hydrogen_Peroxide_Exponent = 8 pH = 7.0 Temperature = 20 pH_Effect = GRAPH(pH) (0.00, 0.00), (1.08, 0.00), (2.15, 0.00), (3.23, 0.00), (4.31, 0.2), (5.38, 0.8), (6.46, 1.00), (7.54, 1.00), (8.62, 0.8), (9.69, 0.2), (10.8, 0.00), (11.8, 0.00), (12.9, 0.00), (14.0, 0.00) Temperature_Effect = GRAPH(Temperature) (0.00, 0.01), (7.14, 0.1), (14.3, 0.5), (21.4, 1.00), (28.6, 1.00), (35.7, 1.00), (42.9, 0.9), (50.0, 0.5), (57.1, 0.005), (64.3, 0.00), (71.4, 0.00), (78.6, 0.00), (85.7, 0.00), (92.9, 0.00), (100.0, 0.00)

THE OUTPUT

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